Hierarchical Organization of Modularity in Metabolic Networks

Hierarchical Organization of Modularity in Metabolic Networks

Hierarchical organization of modularity in metabolic networks.

Spatially or chemically isolated functional modules composed of several cellular components and carrying discrete functions are considered fundamental building blocks of cellular organization, but their presence in highly integrated biochemical networks lacks quantitative support. Here, we show that the metabolic networks of 43 distinct organisms are organized into many small, highly connected ...

Hierarchical Organization of Modularity in Complex Networks

Many real networks in nature and society share two generic properties: they are scale-free and they display a high degree of clustering. We show that the scalefree nature and high clustering of real networks are the consequence of a hierarchical organization, implying that small groups of nodes form increasingly large groups in a hierarchical manner, while maintaining a scale-free topology. In ...

Trapping in scale-free networks with hierarchical organization of modularity.

A wide variety of real-life networks share two remarkable generic topological properties: scale-free behavior and modular organization, and it is natural and important to study how these two features affect the dynamical processes taking place on such networks. In this paper, we investigate a simple stochastic process--trapping problem, a random walk with a perfect trap fixed at a given locatio...

Hierarchical Modularity in Human Brain Functional Networks

The idea that complex systems have a hierarchical modular organization originated in the early 1960s and has recently attracted fresh support from quantitative studies of large scale, real-life networks. Here we investigate the hierarchical modular (or "modules-within-modules") decomposition of human brain functional networks, measured using functional magnetic resonance imaging in 18 healthy v...